People who believe that the methods of science are the only way to understand reality..
I would suggest that there is a subtle difference between understanding and explaining reality.
Understanding is often linked to but not limited by the explanation of something, relating, for instance, to such things as emotional and experiental responses and of interpreting and attaching significance to ideas, events, information etc. Also it does not necessarily follow that an understanding of something means that it is necessarily correct. For instance, it might be quite possible to understand the view that there is some sort of afterlife whilst still holding the view that this is highly unlikely. Hence, understanding, and especially understanding such a vast subject as reality, for me, becomes basically a subjective experience.
Explanation, on the other hand, demands checks and balances to enable it to be the best possible explanation, and, for it to have substance, this should be, as far as possible, least coloured by the proponent's subjective views. Science method, as regards reality, scores heavily, as there seems to be no comparable current discipline which seeks to produce information in as objective a way as possible. However, Sriram is talking about the dogmatic scientism supporter here, (one who believes that only science can deliver the goods), which is an absolute position from which one cannot deviate. Hence it becomes self limiting. This, I suggest, is a position that most scientists would not take.
If, on the other hand, one starts to ry to explain reality in non physical terms, then one cannot use scientific method easily unless one is applying science to the workings of the mind. Hence, in this area, any findings remain squarely in the realm of the subjective and any 'understanding' that has been gathered would be at the mercy of subjective interpretation and biases. This is, of course, not to say that any understanding is wrong per se, only that there is, currently, no means of establishing how correct such understandings are.